Search results for "model [interaction]"
showing 10 items of 1495 documents
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
2021
Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we show that nuclear envelope ruptures induce DNA damage that promotes senescence in non-transformed cells and induces an invasive phenotype in human breast cancer cells. We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1-dependent DNA damage, thereby driving the …
A class of quasi-Newton generalized Steffensen methods on Banach spaces
2002
AbstractWe consider a class of generalized Steffensen iterations procedure for solving nonlinear equations on Banach spaces without any derivative. We establish the convergence under the Kantarovich–Ostrowski's conditions. The majorizing sequence will be a Newton's type sequence, thus the convergence can have better properties. Finally, a numerical comparation with the classical methods is presented.
A new interpretation and practical aspects of the direct-methods modulus sum function. VIII
2001
Since the first publication of the direct-methods modulus sum function [Rius (1993). Acta Cryst. A49, 406-409], the application of this function to a variety of situations has been shown in a series of seven subsequent papers. In this way, much experience about this function and its practical use has been gained. It is thought by the authors that it is now the right moment to publish a more complete study of this function which also considers most of this practical knowledge. The first part of the study relates, thanks to a new interpretation, this function to other existing phase-refinement functions, while the second shows, with the help of test calculations on a selection of crystal stru…
Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles
2019
AbstractInteraction between the transcription factors, hypoxia-inducible factor (HIF1α and HIF2α) and Sp1, mediates hypoxia-driven expression of FVII gene encoding coagulation factor VII (fVII) in ovarian clear cell carcinoma (CCC) cells. This mechanism is synergistically enhanced in response to serum starvation, a condition possibly associated with tumor hypoxia. This transcriptional response potentially results in venous thromboembolism, a common complication in cancer patients by producing procoagulant extracellular vesicles (EVs). However, which deficient serum factors are responsible for this characteristic transcriptional mechanism is unknown. Here, we report that cholesterol deficien…
Issues in Software Inspection Practices
2005
The motivation for this research comes from a need to improve software inspection practices in software organizations. Even if inspections are well defined and regularly used in an organization, there may be some problems which can greatly reduce inspection effectiveness. The paper presents a list of inspection related problems which are known in the literature. It also relates some experiences from two case organizations. In addition, this paper provides an approach which helps identifying problems of this kind and directing limited improvement resources effectively.
A characterization of the line set of an odd-dimensional Baer subspace
1990
Generalizing a theorem of Beutelspacher and Seeger, we consider line sets\(\mathcal{L}\) inP=PG(2t + 1,q),t ∈ IN, with the following properties: (1) any (t + 1)-dimensional subspace ofP contains at least one line of\(\mathcal{L}\), (2) if a pointx ofP is incident with at least two lines of\(\mathcal{L}\) then the points in the factor geometryP/x which are induced by the lines of\(\mathcal{L}\) throughx form a blocking set of type (t, 1) inP/x, (3) any line of\(\mathcal{L}\) is coplanar with at least one further line of\(\mathcal{L}\). We will show that the examples of minimal cardinality are exactly the line sets of Baer subspaces ofP.
Guaranteed Error Bounds I
2014
In Chap. 3, we discussed the main ideas of fully reliable error control methods and the corresponding numerical algorithms with the paradigm of simple elliptic type problems. This chapter is intended to show a deep connection between a posteriori estimates of the functional type and physical relations generating the problem. Also, the goal of this chapter is to consider a wider set of problems arising in various applications and explain things in terms of computational mechanics. For this purpose, we begin with a simple class of mechanical problems (straight beams) and after that consider curvilinear beams and more complicated models of continuum mechanics (linear elasticity, viscous fluids…
On a projective representation of chain geometries
1984
We define a distance d on the set of r-spaces of an n-space. By the transfer of d to the GrasmannianG=G(n, r) we obtain a distinguished class of normal rational curves of order 1, the “1-distance lines’, 1=1,..., r, which are in 1–1-correspondence to the so-called “generalized reguli of type (r, 1)”.
Induced &#x2113;<inf>2</inf> control of discrete-time Takagi-Sugeno fuzzy systems with time-varying delays via dynamic output feedback
2012
This paper is concerned with analyzing a novel model transformation of discrete-time Takagi-Sugeno (T-S) fuzzy systems with time-varying delays and applying it to dynamic output feedback (DOF) controller design. A new auxiliary model is proposed by employing a new approximation for time-varying delay state, and then delay partitioning method is used to analyze the scaled small gain of this auxiliary model. A sufficient condition on discrete-time T-S fuzzy systems with time-varying delays, which guarantees the corresponding closed-loop system to be asymptotically stable and has an induced l 2 disturbance attenuation performance, is derived by employing the scaled small gain theorem. Then the…
Can uncertainty in flood hazard estimation be reduced by using high detailed topographic data for floodplain modelling?
2011
Floods are considered the most frequent natural disaster world-wide and may have serious socio economic impacts in a community. In order to accomplish flood risk mitigation, flood risk analysis and assessment are required to provide information on current or future flood hazard and risks. Hazard and risk maps involve different data, expertise and effort, depending also on the end-users. More or less advanced deterministic approaches can be used, but intuitively probabilistic approaches seem to be more correct and suited for modelling flood inundation given typical uncertainties. Two very important matters remain open for research: the calibration of hydraulic models (oriented towards the es…